Preheat the oven to 350°F. Line an 8x8-inch metal loaf pan with parchment paper, leaving an overhang for easy removal.
In a large bowl, combine the vegan ground beef, diced onion, Panko breadcrumbs, yellow mustard, vegan Worcestershire sauce, black pepper, and cheddar cheese until well blended.
Press the meatloaf mixture into the prepared pan. Bake for 45 minutes or until the internal temperature reaches 160°F.
While the meatloaf is baking, in a small bowl, whisk together the ketchup, brown sugar, yellow mustard, and vegan Worcestershire sauce in a small bowl.
After 45 minutes, remove the loaf from the oven and spread the glaze evenly over the top. Return to the oven for another 10 minutes to set the glaze.
Let the meatloaf stand for at least 10 minutes. Then, lift it from the pan using the parchment paper, slice, and serve warm.